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Any point outside of this space violates one or more of the applied constraints.

Linear optimization can then be applied to identify a solution in the allowable solution space that maximizes or minimizes a defined objective, for example ATP or biomass production [JR904 GSM/GPR accounts for over 904 genes and the 931 unique biochemical reactions the encoded proteins carry out.

In addition to this, Dsb C also shows chaperone activity.

modeling efforts have been made to describe and predict its cellular behavior.

With the vast amounts of '-omics' data that are being generated, there is a growing need for incorporating and reconciling heterogeneous datasets, including genomic, transcriptomic, proteomic and metabolomic data [].

There is currently a need to integrate these datasets within an JR904 GSM/GPR) has been reconstructed which includes 904 genes and 931 unique biochemical reactions.

The reactions in the expanded model are both elementally and charge balanced.

They break non-native disulfide bonds that were formed and act as chaperones for the formation of native disulfide bonds.

However, the probability of forming a non-native disulfide bond increases with the number of cysteines in the protein sequence. Dsb C and Dsb G facilitate the proper folding of the protein by breaking non-native disulfide bonds.

This modeling method finds the limits of cellular, biochemical and systemic functions, thereby identifying all allowable solutions.

Searches within the allowable solution space can identify solutions of interest, for example a solution that maximizes a particular objective.

Coli Reteplase is used in the treatment of ischemic stroke and contains 9 disulfide bonds.

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